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The aim is to illustrate the atypical presentation of Guillain-Barré syndrome and its potential to mimic an acute stroke.

April 16, 2026CureusOpen Access

Atypical Unilateral-Onset Guillain-Barré Syndrome Mimicking Acute Stroke: A Case Report

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The aim is to illustrate the atypical presentation of Guillain-Barré syndrome and its potential to mimic an acute stroke.
Detailed neurological examination
Cerebrospinal fluid analysis demonstrating albuminocytologic dissociation
Nerve conduction studies confirming demyelinating polyneuropathy
Monitoring in intensive care unit for respiratory compromise
Administration of intravenous immunoglobulin
Initial misdiagnosis of acute stroke due to unilateral limb weakness
Progression of weakness to involve both lower limbs and sensory loss
Respiratory compromise necessitating intubation and ICU care
Gradual clinical improvement following intravenous immunoglobulin treatment

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Case report describes atypical guillain-barré syndrome misdiagnosed as a stroke, emphasizing the need for careful evaluation.

Mobaideen et al. (2026) studied this question.

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