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April 16, 2026Annals of HematologyOpen Access

Effects of vitamin D deficiency and supplementation on myocardial and hepatic iron status and function in children with beta-thalassemia

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Authors

HSHüseyin Avni SolğunGaziantep Children's HospitalMÖMustafa ÖzayGaziantep Children's Hospital

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Implication

Cross-sectional study examines vitamin D effects on iron levels and organ function in children with beta-thalassemia, suggesting important management benefits.

Key Points

  • The study evaluates how vitamin D deficiency and supplementation affect cardiac and liver iron levels in children with beta-thalassemia.
  • Cross-sectional observational study in pediatric hematology department.
  • Included children older than three with transfusion-dependent beta-thalassemia.
  • Measured serum vitamin D, calcium, phosphate, and parathyroid hormone levels.
  • Assessed cardiac and hepatic iron using T2* MRI and left ventricular ejection fraction via echocardiography.
  • Categorized patients into deficiency groups based on serum 25(OH)D levels.
  • Significant improvements in cardiac and hepatic T2* MRI values post-vitamin D supplementation (p < 0.05).
  • Vitamin D supplementation improved myocardial and hepatic iron measures considerably.
  • Routine monitoring and management of vitamin D in these patients are emphasized.

Cite This Study

Solğun et al. (2026) studied this question.

synapsesocial.com/papers/69e07d1d2f7e8953b7cbe301https://doi.org/10.1007/s00277-026-06978-2
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vitamin D Deficiency2007 · 13,752 citations
  2. 2MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients2005 · 1,045 citations