What question did this study set out to answer?

This research aims to develop a selective and efficient method for synthesizing P(O)–C and P(O)–O bonds using Mn(II) catalysis.

April 16, 2026Chemical Communications0 citations

Mn(II)-Catalyzed Switchable Synthesis of P(O)–C and P(O)–O Bonds from Alcohols and Diarylphosphine Oxides via Phospha-Brook Rearrangement

HPHirak Jyoti PhukanIndian Institute of Technology Guwahati ASArup SamantaIndian Institute of Technology Guwahati KMKailash MoharIndian Institute of Technology Guwahati

Key Points

This research aims to develop a selective and efficient method for synthesizing P(O)–C and P(O)–O bonds using Mn(II) catalysis.
Utilized Mn(II) as a catalyst for selective bond formation
Employed alcohols and diarylphosphine oxides as starting materials
Explored the Phospha–Brook rearrangement mechanism
Successfully synthesized both P(O)–O and P(O)–C compounds
Demonstrated a broad substrate scope for various alcohols
Highlighted the biocompatibility and economic viability of the method.

Abstract

We describe a Mn(II)-catalyzed, biocompatible, and economical strategy for selective and efficient synthesis of both P(O)–O and P(O)–C compounds via a dehydrogenative Phospha–Brook rearrangement, with broad substrate scope and mechanistic...

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