Macrocyclic Peptides as Protein-Protein Interaction Modulators: A Review

Key Points

• This review aims to explore the role of macrocyclic peptides in modulating protein-protein interactions and their implications for therapeutics.
• Reviewed existing literature on macrocyclic peptides and their interactions with proteins.
• Analyzed the mechanisms of action for these peptides in biological systems.
• Examined therapeutic applications based on modulation of protein-protein interactions.
• Identified key mechanisms by which macrocyclic peptides enhance or inhibit protein-protein interactions.
• Highlighted several therapeutic applications where these peptides show promise in drug development.
• Noted the potential of macrocyclic peptides in targeting previously undrugged protein interactions.