Macrocyclic Peptides as Protein-Protein Interaction Modulators: A Review

Erin Ann Sunny Sunny; Sandhya Sadanandan

doi:10.1039/d6ob00106h

January 1, 2025Organic & Biomolecular Chemistry

Macrocyclic Peptides as Protein-Protein Interaction Modulators: A Review

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Key Points

This review aims to explore the role of macrocyclic peptides in modulating protein-protein interactions and their implications for therapeutics.
Reviewed existing literature on macrocyclic peptides and their interactions with proteins.
Analyzed the mechanisms of action for these peptides in biological systems.
Examined therapeutic applications based on modulation of protein-protein interactions.
Identified key mechanisms by which macrocyclic peptides enhance or inhibit protein-protein interactions.
Highlighted several therapeutic applications where these peptides show promise in drug development.
Noted the potential of macrocyclic peptides in targeting previously undrugged protein interactions.

Implication

Review discusses how macrocyclic peptides affect protein-protein interactions, suggesting potential therapeutic applications.

Abstract

Protein-protein interactions (PPIs) are essential for cellular function, mediating processes such as signal transduction, enzymatic catalysis, and the formation of macromolecular complexes. PPIs are crucial for targeting therapeutics, as disruptions...

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Cite This Study

Sunny et al. (2025) studied this question.

synapsesocial.com/papers/69e07d3c2f7e8953b7cbe411 https://doi.org/10.1039/d6ob00106h

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Macrocyclic Peptides as Protein-Protein Interaction Modulators: A Review

Key Points

Implication

Abstract

Discussion

Cite This Study

Macrocyclic Peptides as Protein-Protein Interaction Modulators: A Review

Key Points

Implication

Abstract

Discussion

Cite This Study

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