What question did this study set out to answer?

To evaluate the effectiveness of parenteral clomipramine for treating depression and obsessive-compulsive disorder compared to oral administration.

April 16, 2026Open Access

Parenteral Clomipramine for Depression or Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis

MIMichael IoannouTechnological Educational Institute of Central Greece ÖFÖrjan FalkSahlgrenska University Hospital JGJoss GustavssonSahlgrenska University Hospital

Key Points

To evaluate the effectiveness of parenteral clomipramine for treating depression and obsessive-compulsive disorder compared to oral administration.
Conducted systematic review of available studies
Performed meta-analysis of relevant trials
Assessed comparisons with other treatments like electroconvulsive therapy and ketamine
Parenteral clomipramine is less favorable compared to oral administration
Lack of relevant randomized controlled trials for direct comparisons with electroconvulsive therapy and ketamine

Abstract

Current evidence indicates that parenteral administration of clomipramine may not be favourable compared to oral administration, and RCTs with relevant comparisons such as electroconvulsive therapy and ketamine are lacking.

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