Interaction of bi-nuclear gallium(III) complexes with human serum albumin and impact on potency towards osteosarcoma stem cells

Xiao Feng; Kogularamanan Suntharalingam

doi:10.1039/d6dt00591h

January 1, 2026Dalton TransactionsOpen Access

Interaction of bi-nuclear gallium(III) complexes with human serum albumin and impact on potency towards osteosarcoma stem cells

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Key Points

The study aims to investigate how bi-nuclear gallium(III) complexes interact with human serum albumin and affect osteosarcoma stem cells.
Analyzed the binding of gallium complexes to human serum albumin.
Examined the effects on osteosarcoma stem cells' growth and differentiation.
Used biochemical assays to determine potency levels of gallium complexes against stem cell populations.
Gallium complexes show significant binding affinity for human serum albumin.
The presence of these complexes reduces the viability of osteosarcoma stem cells.
Potency against resistant stem cell populations increases with gallium complex concentration.

Implication

Research demonstrates interactions between gallium complexes and human serum albumin, impacting osteosarcoma stem cell potency.

Abstract

Metastasised osteosarcoma has very poor survival rates, in part due to the presence of osteosarcoma stem cells (OSCs), a resistant subpopulation with self-renewal and differentiation capabilities. Recently, we reported the...

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Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/69e07d8f2f7e8953b7cbe875 https://doi.org/10.1039/d6dt00591h

View Full Paper

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Interaction of bi-nuclear gallium(III) complexes with human serum albumin and impact on potency towards osteosarcoma stem cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Interaction of bi-nuclear gallium(III) complexes with human serum albumin and impact on potency towards osteosarcoma stem cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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