What question did this study set out to answer?

This research aims to investigate the prevalence of motoric cognitive risk syndrome (MCR) and its associations with various factors in older adults.

April 16, 2026

Motoric cognitive risk syndrome among community-dwelling older adults in China: Prevalence, associated factors, and adverse outcomes

Key Points

This research aims to investigate the prevalence of motoric cognitive risk syndrome (MCR) and its associations with various factors in older adults.
Cross-sectional analysis of 5,242 older adults aged ≥60 years from CHARLS
Used Boruta algorithm for feature selection
Employed multivariate logistic regression and XGBoost for analysis
MCR prevalence was found to be 12.9%
Significant associations identified with physical performance measures
Higher education and social activity inversely related to MCR
MCR prospectively linked to increased ADL disability

Abstract

Introduction: Motoric cognitive risk syndrome (MCR) is a screening syndrome that has been associated with increased dementia risk in prior studies. This study aimed to investigate the prevalence, associated factors, and adverse outcomes of MCR among community-dwelling older adults in China. Methods: A cross-sectional analysis was conducted among 5,242 CHARLS participants aged ≥60 years to examine factors associated with prevalent MCR, and prospective outcomes were evaluated over a 3-year follow-up. The Boruta algorithm was used for feature selection. Multivariate logistic regression analysis was employed to assess associations, while XGBoost was applied as a complementary baseline classification approach to rank feature importance for distinguishing prevalent MCR. Results: The prevalence of MCR was 12.9% among the study population, with higher rates in unmarried, illiterate, and older participants. Physical performance measures emerged as the strongest associated factors, with five-time sit-to-stand test (OR=1.05, 95%CI: 1.03-1.07), handgrip strength (OR=0.98, 95%CI: 0.97-0.99), and mobility score (OR=1.12, 95%CI: 1.04-1.19) showing significant associations. Higher education level (OR=0.67, 95%CI: 0.51-0.89) and social activity participation (OR=0.69, 95%CI: 0.58-0.82) were inversely associated with prevalent MCR, while stroke (OR=2.18, 95%CI: 1.43-3.24), visual impairment (OR=1.40, 95%CI: 1.08-1.84), and poor self-reported health status (OR=1.50, 95%CI: 1.13-2.00) were associated with higher odds of prevalent MCR. MCR was prospectively associated with ADL disability (adjusted OR=1.40, 95% CI: 1.12–1.73) but not hospitalization (adjusted OR=1.08, 95% CI: 0.87–1.34). Conclusion: These findings underscore the importance of incorporating physical performance measures and social factors in MCR screening protocols and may inform screening and risk stratification in aging populations.

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