What question did this study set out to answer?

This study aims to evaluate the effectiveness of 5,7-dihydroxy-3(R)-methylphthalide in treating ovarian cancer.

April 16, 2026Journal of Herbmed PharmacologyOpen Access

A promising computational study of ovarian cancer treatment of the isolated compound 5,7-dihydroxy-3( R )-methylphthalide

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Authors

AAAgus Dwi Ananto TOTendy OktriawanUniversitas Gadjah Mada KGKasta Gurning

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Implication

Computational analysis identifies the SRC protein as a target for 5,7-dihydroxy-3(R)-methylphthalide in ovarian cancer, suggesting promising therapeutic potential.

Key Points

This study aims to evaluate the effectiveness of 5,7-dihydroxy-3(R)-methylphthalide in treating ovarian cancer.
Utilized bioinformatics and network pharmacology to collect data on active compounds and genes related to ovarian cancer.
Predicted target interactions and performed molecular docking and dynamics simulations.
Conducted ADMET analysis to assess safety and compatibility with drug-like properties.
Identified SRC protein as a key target among 28 potential genes for ovarian cancer.
Substantial hydrogen bond interactions and strong binding affinity through molecular docking.
Confirmed compound stability in molecular dynamics simulations over 100 ns.

Cite This Study

Ananto et al. (2026) studied this question.

synapsesocial.com/papers/69e07e992f7e8953b7cbf77f https://doi.org/10.34172/jhp.2026.53027

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Implication

Computational analysis identifies the SRC protein as a target for 5,7-dihydroxy-3(R)-methylphthalide in ovarian cancer, suggesting promising therapeutic potential.

A promising computational study of ovarian cancer treatment of the isolated compound 5,7-dihydroxy-3( R )-methylphthalide

Discussion

Member takes

Implication

Key Points

Cite This Study

A promising computational study of ovarian cancer treatment of the isolated compound 5,7-dihydroxy-3( R )-methylphthalide

Discussion

Member takes

Implication

Key Points

Cite This Study

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