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This research aims to investigate the role of Treg cells and the PD-1 pathway in immune response among tuberculosis patients.

September 19, 2012PLoS ONEOpen Access

Foxp3+ Regulatory T Cells among Tuberculosis Patients: Impact on Prognosis and Restoration of Antigen Specific IFN-γ Producing T Cells

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Randomized trial evaluates role of Treg cells in immune response among tuberculosis patients, suggesting significant implications for therapy.

This research aims to investigate the role of Treg cells and the PD-1 pathway in immune response among tuberculosis patients.
Utilized multicolor flow cytometry, cell culture, cell sorting, and ELISA for analysis.
Evaluated antigen-reactive Treg cell frequency and cytokine production in pulmonary tuberculosis patients.
Treg cell frequency increased among patients, declining during successful therapy along with IL-10 and increasing IFN-γ levels.
Persistence of Treg cells correlated with multidrug-resistant tuberculosis.
Blocking PD-1/PD-L1 pathway eliminated Treg suppression, restoring protective T cell response.

Singh et al. (2012) studied this question.

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Randomized trial evaluates role of Treg cells in immune response among tuberculosis patients, suggesting significant implications for therapy.