Does impaired renal clearance explain the elevated levels of serum cTnT fragments in hemodialysis patients?
Unexplained elevations of serum cTnT in patients with severe renal failure are likely due to the accumulation of cTnT fragments resulting from impaired renal clearance.
cTnT is fragmented into molecules small enough to be cleared by the kidneys of healthy subjects. Impaired renal function causes accumulation of these cTnT fragments and is very likely the cause of the unexplained elevations of serum cTnT found in patients with severe renal failure.
Diris et al. (Tue,) studied this question.
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