The Strong β−CF₃ Shielding Effect in Hexafluoroisopropanol and 100 Other Organic Solvents Revisited with ¹⁷O NMR Spectroscopy

An 17 O NMR spectroscopy survey of more than 100 ubiquitous organic solvents and compounds, including some typical oxofluorinated solvents such as hexafluoroisopropanol, trifluoroethanol, trifluoroacetic acid, and others, is presented with D 2 O as a reference. A strong alternating α,β−CF 3 ‐substituent chemical shift effect was thus observed. This alternating deshielding–shielding effect is suspected to have a role in the exceptional properties of these oxofluorinated solvents, notably in oxidative cross‐coupling reactions.