Findings demonstrate sleep deprivation worsens Parkinson's disease through astrocytic LAG3 upregulation, suggesting treatment avenues.
Our findings identify astrocytic LAG3 as a critical mediator linking sleep deprivation to glymphatic dysfunction and PD progression. Targeting LAG3 may represent a promising, albeit early-stage, therapeutic strategy to mitigate α-syn pathology in PD patients with sleep disorders.
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Sun et al. (2026) studied this question.
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