What question did this study set out to answer?

The study aims to evaluate the long-term efficacy and safety of single-fraction Gamma Knife radiosurgery for pineal region meningiomas.

Single-fraction Gamma Knife radiosurgery for pineal region meningiomas: a retrospective single-center cohort of 44 patients

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Retrospective cohort evaluates long-term outcomes of Gamma Knife radiosurgery in meningiomas, implying its effectiveness as primary treatment.

The study aims to evaluate the long-term efficacy and safety of single-fraction Gamma Knife radiosurgery for pineal region meningiomas.
Retrospective cohort study of 44 patients with pineal region meningiomas treated with Gamma Knife radiosurgery.
Tumor response assessed using contrast-enhanced MRI, defining regression, stability, and progression.
Local control, progression-free survival, overall survival, and adverse effects analyzed over 90 months follow-up.
Local control achieved in 42 out of 44 patients (95.5%), with 29.5% showing regression and 65.9% stability.
Kaplan-Meier local control rates were 100% at 2 years, 97.1% at 5 years, and 86.3% at 10 years.
Progression-free survival rates were 100%, 94.1%, and 72.6% at 2, 5, and 10 years, respectively.
Adverse radiation effects occurred in 3 patients (6.8%), none resulting in long-term issues.
Karnofsky Performance Scale outcomes remained stable or improved for all patients.

Duzkalir et al. (2026) studied this question.

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Retrospective cohort evaluates long-term outcomes of Gamma Knife radiosurgery in meningiomas, implying its effectiveness as primary treatment.