Key result
Nivolumab-induced myocarditis presents with high-grade AV block and neuromuscular symptoms requiring prompt immunosuppression.
Why the study?
Immune checkpoint inhibitor-induced myocarditis is rare but potentially life-threatening and can present with subtle or atypical symptoms, including conduction abnormalities, creating diagnostic and therapeutic challenges.
Case Report (n=1)
This case highlights the importance of early recognition and prompt immunosuppressive therapy for life-threatening ICI-induced myocarditis presenting with high-grade AV block.
Warrants heightened vigilance for cardiotoxicity during immune checkpoint inhibitor therapy; hypothesis-generating for prospective cardio-oncology studies.
Immune checkpoint inhibitors (ICIs) are increasingly used in the treatment of several cancer types, but can cause immune-related adverse events (irAEs) such as myocarditis.ICI-induced myocarditis is rare but potentially life threatening and may present with subtle or atypical symptoms, including conduction abnormalities.We describe a case of nivolumab-induced myocarditis in a patient receiving adjuvant therapy for esophageal cancer, presenting with high-grade atrioventricular block and neuromuscular symptoms, highlighting the diagnostic and therapeutic challenges of ICI-induced myocarditis.The case underscores the importance of early recognition, comprehensive diagnostic evaluation, prompt initiation of immunosuppressive therapy, and individualized management of conduction disturbances.Early detection and intervention are key to mitigating risks and improving outcomes in this rare but serious irAE.
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Strijdhorst et al. (2026) conducted a case report in Nivolumab-induced myocarditis (n=1). Nivolumab was evaluated. Nivolumab-induced myocarditis in a patient with esophageal cancer presented with high-grade atrioventricular block and neuromuscular symptoms, requiring prompt immunosuppressive therapy.
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