Primary bone cancer (PBC) is a rare type of malignancy that originates in the bones and constitutes 0.2% of all tumor types worldwide. While chronic kidney disease (CKD) is known to increase the risk of various cancers, its association with PBC remains unclear. PBC and CKD are also known to be determined by biological, social, and behavioral characteristics that can affect their risk. Nonetheless, the links between these factors, CKD and PBC, are not assessed yet, posing an under-examined area of research that we aim to address in this study. Our analysis is based on a secondary data analysis of a cross-sectional study adopted from the 2022 Behavioral Risk Factor Surveillance System (BRFSS). Weighted Chi-square test and weighted multiple logistic regressions were employed for data analysis. Out of 208,260 participants, 55 individuals were diagnosed with PBC, while 205,689 did not report having PBC. Moreover, 7,557 had kidney disease. Patients with CKD had more than five times higher odds of developing PBC (OR: 5.61, 95% CI: 1.56–20.18). Biological variables mainly age and sex were significant factors associated with both CKD and PBC, and obesity was a risk factor for both CKD and PBC, but statistical significance was reached only with CKD. Race was an index of social determinants of health that correlated marginally with PBC and significantly with CKD. Our findings highlight the interrelationships between CKD, biological and social determinants of health, and PBC, suggesting an elevated risk of PBC among individuals with CKD. This finding is novel and warrants future mechanistic examination to determine the biological links between these two diseases while factoring in the effects of non-clinical health characteristics.
Shouman et al. (Wed,) studied this question.