Amyloid Formation In the Research Article (e06612), Jong Min Yuk and co-workers illustrate the early-stage dynamics of amyloid-β oligomer formation in a liquid-flowing graphene liquid cell. Transient assemblies undergo rapid association–dissociation while maintaining a quasi-equilibrium population. A multimodal framework integrating semi-ensemble population analysis with time-sequential single-particle tracking reveals dynamic aggregation pathways beyond conventional ensemble-averaged approaches.
Park et al. (Wed,) studied this question.