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April 17, 2026Journal of Parkinson s DiseaseOpen Access

Elevated plasma neurofilament light chain in isolated REM sleep behavior disorder: Associations with neurogenic orthostatic hypotension and implications for phenoconversion

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Authors

ACAlessandra CalculliUniversity of Pavia DMD. Di MartinoUniversity of Pavia PGPiergiorgio GrilloAOL (United States)

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Implication

Observational study shows elevated neurofilament light chain levels in isolated REM sleep behavior disorder, suggesting links to neurogenic orthostatic hypotension and disease progression.

Key Points

The study aims to evaluate plasma neurofilament light chain levels in isolated REM sleep behavior disorder patients and their associations with clinical features.
Measured plasma neurofilament light chain levels in 54 iRBD subjects, alongside 54 PD patients, 54 healthy controls, and 16 MSA patients.
Conducted assessments for motor, cognitive, and non-motor symptoms.
Utilized the Ella platform for NfL quantification and performed data analysis with Prism 9.
Plasma NfL levels were significantly higher in iRBD compared to controls and similar to PD.
iRBD patients with neurogenic orthostatic hypotension had higher NfL levels than those without.
Neurogenic orthostatic hypotension showed an inverse relationship with hyposmia.
NfL correlated positively with SCOPA-AUT and BDI scores.

Cite This Study

Calculli et al. (2026) studied this question.

synapsesocial.com/papers/69e1ce895cdc762e9d857931 https://doi.org/10.1177/1877718x261418988

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Implication

Observational study shows elevated neurofilament light chain levels in isolated REM sleep behavior disorder, suggesting links to neurogenic orthostatic hypotension and disease progression.

Elevated plasma neurofilament light chain in isolated REM sleep behavior disorder: Associations with neurogenic orthostatic hypotension and implications for phenoconversion

Discussion

Member takes

Implication

Key Points

Cite This Study

Elevated plasma neurofilament light chain in isolated REM sleep behavior disorder: Associations with neurogenic orthostatic hypotension and implications for phenoconversion

Discussion

Member takes

Implication

Key Points

Cite This Study

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