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April 17, 2026ACS OmegaOpen Access

Copper(I)-Catalyzed Stereoselective Synthesis of 4-(Aminomethylene)-1,4-dihydroisoquinolin-3-ones from 4-Diazo-1,4-dihydroisoquinolin-3-ones and Thioamides

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Authors

YWYingxiao WangUniversity of Southern CaliforniaYWYingxiao WangUniversity of Southern CaliforniaJFJiale FanZhejiang University

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Implication

Novel synthesis method generates 4-(aminomethylene)-1,4-dihydroisoquinolin-3-ones, indicating practical applications in organic chemistry.

Key Points

  • The research aims to develop an efficient method for synthesizing 4-(aminomethylene)-1,4-dihydroisoquinolin-3-ones using copper(I) catalysis.
  • Copper(I)-catalyzed coupling reaction
  • Starting materials include 4-diazo-1,4-dihydroisoquinolin-3-ones and thioamides
  • Synthesized compounds characterized for stereochemistry
  • Products synthesized in good to excellent yields
  • Primary and secondary thioamides yield (Z)-configured compounds
  • Tertiary thioamides yield (E)-configured products

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69e1cecc5cdc762e9d857c1ahttps://doi.org/10.1021/acsomega.6c01111
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