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April 17, 2026Nature CommunicationsOpen Access

Assembling a single active pocket from enzyme and metal modules for simultaneously catalyzing oxidation-reduction cascades

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Authors

YFYunkai FanJHJia HuQWQilu Wu

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Overview

This research demonstrates enhanced oxidation-reduction cascades in enzyme-metal hybrids, indicating a novel catalytic approach.

Key Points

  • The research aims to create an active pocket combining enzymes and metal modules to improve cascade reaction efficiency.
  • Assembly of enzymatic and dual metal-single-atom photocatalytic modules into one active pocket.
  • Evaluation of catalytic performance in simultaneous hydrogenation and oxidation reactions.
  • Investigation of diffusion resistance reduction in catalytic processes.
  • The enzyme-metal hybrid pocket shows excellent performance in catalyzing two reactions simultaneously.
  • Diffusion resistance of intermediates is significantly decreased, enhancing overall reaction efficiency.
  • The method successfully detoxifies low-concentration mycotoxins, a previously challenging task.

Cite This Study

Fan et al. (2026) studied this question.

synapsesocial.com/papers/69e1cecc5cdc762e9d857c58https://doi.org/10.1038/s41467-026-72061-z
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