What question did this study set out to answer?

This research aims to explore the role of TFRC in promoting ferroptosis and its impact on breast cancer bone metastasis.

April 17, 2026Breast Cancer ResearchOpen Access

TFRC promotes ferroptosis to suppress breast cancer bone metastasis via the activation of HIF-1 pathway

View Full Paper

Ask AI

Bookmark

Authors

Research demonstrates TFRC regulates ferroptosis in breast cancer bone metastasis, suggesting a new therapeutic target.

This research aims to explore the role of TFRC in promoting ferroptosis and its impact on breast cancer bone metastasis.
Transcriptome sequencing to identify differentially expressed genes in a mouse model.
In vitro validation using gain/loss-of-function studies on MCF-7 and MDA-MB-231 cell lines.
Analysis of ferroptosis markers and epithelial-mesenchymal transition-related proteins.
In vivo experiments employing a BALB/c nude mouse intratibial model.
Bioinformatics to uncover regulatory pathways involving HIF-1.
TFRC was identified among the top 10 hub genes significantly downregulated in bone metastasis.
Overexpression of TFRC suppressed tumor growth and induced ferroptosis in both in vivo and in vitro models.
Increased E-cadherin and decreased N-cadherin were observed with TFRC overexpression.
The HIF-1 pathway was confirmed as a downstream target of TFRC.
PX-478 treatment reduced TFRC-mediated ferroptosis induction.

Liu et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark