This evaluation reveals pervasive unblinding in psychedelic trials, suggesting a need for improved study designs.
This first evaluation of blinding integrity in psychedelic RCTs indicates functional unblinding is pervasive among participants and raters raising concerns about the validity of efficacy findings. Few trials assess blinding or expectancy, highlighting the need for standardized, validated measures and innovative designs to separate true pharmacological effects from expectancy-driven responses.
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Orsini et al. (2026) studied this question.
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