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April 17, 2026Antimicrobial Agents and Chemotherapy0 citationsOpen Access

Identification and characteristics of a novel fosfomycin glutathione transferase, FosA12, from an MDR clinical isolate of Proteus vulgaris

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WLWei LuLLLi LiBGI Group (China)XLXi LinInner Mongolia Agricultural University

Key Points

  • The aim is to identify and characterize the novel fosfomycin resistance gene fosA12 in a multidrug-resistant isolate.
  • Conducted whole-genome sequencing on a clinical isolate of Proteus vulgaris.
  • Characterized fosA12 gene and compared its homology with similar genes.
  • FosA12 shows 64.23% homology with the fosA gene from Pseudomonas aeruginosa.
  • FosA12 confers high-level fosfomycin resistance with a minimum inhibitory concentration (MIC) of 512 μg/mL.
  • Identified five critical residues contributing to fosfomycin resistance.

Abstract

This study identifies fosA12, a novel chromosomally encoded fosfomycin resistance gene in a multidrug-resistant Proteus vulgaris clinical isolate. Through whole-genome sequencing, fosA12 was characterized, showing 64.23% homology with Pseudomonas aeruginosa's fosA. FosA12, a glutathione S-transferase, confers high-level fosfomycin resistance (MIC 512 μg/mL) via five critical residues. These findings highlight fosA12's role in resistance and the need for clinical surveillance.

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Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/69e1cf1b5cdc762e9d858001https://doi.org/10.1128/aac.01138-25
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