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Cross-sectional study correlates hemodynamic responses in the prefrontal cortex with depression severity, suggesting vulnerability insights.
Our findings align with clinical and preclinical evidence linking disrupted neurovascular function in the prefrontal cortex to depression pathophysiology. Poststimulation responses in the stimulated dlPFC, reflecting the current state and multiple prior episodes, show potential for aiding in differential diagnosis and indicating depression vulnerability. Longitudinal studies are needed to determine whether such neurological dysfunctions represent disease progression or a vulnerability biomarker.
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Jin et al. (2026) studied this question.
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