Animal study demonstrates that semaglutide decreases cocaine preference in rats, suggesting its potential in treating cocaine use disorder.
The present study determined the effectiveness of the glucagon-like peptide 1 agonist semaglutide to attenuate cocaine-vs-food choice in male and female rats. Repeated 5-day semaglutide treatment decreased cocaine choice and significantly reduced body weight. These preclinical results support the clinical evaluation of semaglutide as a candidate cocaine use disorder medication.
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Heslep et al. (2026) studied this question.
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