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April 17, 2026Cell Biochemistry and Function

MMP9 Serves as a Prognostic Biomarker and Immune‐Associated Regulator in Diffuse Large B‐Cell Lymphoma

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Authors

JLJunXiu LiuJQJiaQi QinXSXiaojing Shi

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Overview

Analysis uncovers MMP9's role in tumor survival and immune alterations in DLBCL, suggesting new therapeutic insights.

Key Points

  • To investigate the clinical relevance and immune-related roles of MMP9 in diffuse large B-cell lymphoma.
  • Analyzed publicly available DLBCL datasets from TCGA and GSE56315.
  • Conducted differential expression and enrichment analyses for MMP9.
  • Used CIBERSORT, TIMER, and ESTIMATE algorithms to assess immune features.
  • Examined peripheral blood leukocyte profiles in an independent DLBCL cohort.
  • Performed immunohistochemical analysis for MMP9 protein expression.
  • MMP9 expression was significantly higher in DLBCL tissues than in normal controls.
  • Elevated MMP9 correlated with poorer overall survival and altered immune-stromal scores.
  • Increased monocyte and myeloid infiltration was associated with high MMP9 levels.
  • Distinct mutational patterns were observed in MMP9-high tumors.
  • Peripheral blood analysis showed shifts in leukocyte distributions in DLBCL patients.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69e1cf1b5cdc762e9d85806dhttps://doi.org/10.1002/cbf.70200
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