Complement Inhibition Therapy in Myasthenic Crisis—A Multicentre Retrospective Analysis of 17 Cases From Germany

Key Points

This analysis aims to evaluate the effectiveness of complement inhibition therapy in patients experiencing myasthenic crisis not responding to standard treatments.
Retrospective analysis of 17 cases from multiple centers in Germany.
Focus on patients experiencing myasthenic crisis unresponsive to IVIg and PLEX/IA.
Assessment of clinical improvement with add-on C5-I therapy.
Patients demonstrated clinical improvement after receiving C5-I therapy.
TAMG cases, typically excluded from trials, also responded positively to the treatment.
Findings support further investigation into C5-I therapy as an adjunct for refractory cases.

Multicenter analysis demonstrates clinical improvement from C5-I therapy in myasthenic crisis, highlighting its potential as an adjunctive treatment.

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Gerischer et al. (2026) studied this question.

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