Research illustrates light-guided patterning to increase throughput in single-molecule force spectroscopy, suggesting enhanced experimental efficiency.
Molecular Patterning In the Research Article (e11065), Wesley P. Wong and co-workers illustrate spatially organized, light-responsive oligonucleotides assembled on a solid substrate with high programmability. UV illumination patterns are projected by a digital micromirror device, enabling precise and flexible spatial control without the need for photomasks. This light-guided molecular patterning strategy provides a versatile and accessible approach to increase throughput in single-molecule force spectroscopy experiments.
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Choi et al. (2026) studied this question.
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