Despite increased interest in virus survival on surfaces, data on bovine herpesvirus type 1 (BoHV-1) interactions with metal surfaces remain limited. This study aimed to assess the effects of copper, zinc, and iron on BoHV-1 viability, viral titre, and DNA stability under different conditions. MDBK-adapted BoHV-1 was used to investigate the virucidal effect of copper, zinc and stainless steel surfaces. The virus was exposed for 1 and 24 h under both wet and dry conditions. Inactivation was assessed based on changes in TCID50 log10 values, qPCR Ct results, and calculating half-lives of the virus and its DNA. Virus stability varied depending on surface type, environmental conditions, and duration of exposure. Copper demonstrated the strongest virucidal effect, significantly reducing viral titres and DNA levels under all conditions. After 1 h in wet conditions, copper reduced viral titre to 4.7 log10, while zinc and stainless steel showed minimal impact. Under dry conditions, copper reduced viral titres to the limit of detection after 24 h. Half-life analysis confirmed rapid inactivation on copper, with the shortest persistence observed across all conditions. Zinc showed moderate virucidal activity but required longer exposure times. These findings highlight copper’s superior antiviral properties and suggest its potential application in reducing viral transmission on surfaces.
Grigauskaitė et al. (Wed,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: