A Compound Heterozygous Missense Variant in The DNAH5 Gene Could Be A Significant Factor in Unexplained Male Infertility: A Case Study.

Maryam Afkari; Najmeh Salehi; Hesamoddin Sajadi; Marjan Sabbaghian; Seyed Abolhassan Shahzadeh-Fazeli; Amir Amiri-Yekta

doi:10.22074/ijfs.2025.2051131.1811

April 13, 2026

A Compound Heterozygous Missense Variant in The DNAH5 Gene Could Be A Significant Factor in Unexplained Male Infertility: A Case Study.

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Key Points

To explore the significance of a compound heterozygous missense variant in the DNAH5 gene in relation to male infertility.
Analyzed genetic variants within a family experiencing male infertility.
Used in silico structural predictions to assess the impact of DNAH5 variants.
Identified a compound heterozygous missense variant in the DNAH5 gene.
Structural predictions suggest potential links between the variant and fertility issues.

Implication

Case study reports a missense variant in DNAH5 linked to male infertility, suggesting a genetic role.

Abstract

Our study reports a CH presence of a missense variant in DNAH5 within a family experiencing male infertility. In silico structural predictions suggest a potential role of these DNAH5 variants in causing fertility issues.

Discussion

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Cite This Study

Afkari et al. (2026) studied this question.

synapsesocial.com/papers/69e1cfb15cdc762e9d858a0f https://doi.org/10.22074/ijfs.2025.2051131.1811

View at Publisher

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A Compound Heterozygous Missense Variant in The DNAH5 Gene Could Be A Significant Factor in Unexplained Male Infertility: A Case Study.

Key Points

Implication

Abstract

Discussion

Cite This Study

A Compound Heterozygous Missense Variant in The DNAH5 Gene Could Be A Significant Factor in Unexplained Male Infertility: A Case Study.

Key Points

Implication

Abstract

Discussion

Cite This Study

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