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April 17, 2026S S Korsakov Journal of Neurology and Psychiatry

Neurological disorders induced by nitrous oxide abuse: analysis of 57 clinical cases

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Authors

NTN.N. TurovetsDGD.A. GrishinaNSN.A. Suponeva

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Overview

Analysis reports neurological complications in patients abusing nitrous oxide, suggesting the need for prompt treatment interventions.

Key Points

  • This research aims to analyze neurological disorders from nitrous oxide abuse and assess the effectiveness of treatment regimens.
  • Analyzed clinical and paraclinical data from 57 patients with a history of nitrous oxide abuse.
  • Patients evaluated for neurological complications and treated for vitamin B12 deficiency.
  • Follow-up assessed improvement in vitamin B12 and homocysteine levels.
  • Sensory ataxia occurred in 79% of patients, while polyneuritic disorders were seen in 63%.
  • Vitamin B12 deficiency was present in 65% of cases, and hyperhomocysteinemia was found in 93%.
  • MRI confirmed spinal cord degeneration in 33% of cases, with significant peripheral nerve changes observed.

Cite This Study

Turovets et al. (2026) studied this question.

synapsesocial.com/papers/69e1cfb15cdc762e9d858b19https://doi.org/10.17116/jnevro202612603125
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Also Consider

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  1. 1Laughing gas abuse causing subacute combined spinal cord degeneration with psychiatric manifestations2024 · 1 citations
  2. 2Disturbances in Biological Parameters in Patients Exposed to Nitrous Oxide Abuse Experience of the Rene Dubos Hospital Centre in Pontoise2024
  3. 3Nitrous oxide abuse in a 21-year-old female: a case report and review of literature2024
  4. 4Nitrous Oxide–Associated Myelopolyneuropathy—A Case Series2025
  5. 5Nitrous oxide abuse prevalence, mechanisms, treatments and prevention2026