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September 10, 2025Journal of Clinical Neuromuscular Disease

Nitrous Oxide–Associated Myelopolyneuropathy—A Case Series

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Authors

MCMichele CavalliAEAndra EzaruAOAlberto Olivero

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Overview

This case series reports sensory impairment and motor neuropathy related to nitrous oxide use, suggesting awareness of neurological complications is crucial.

Key Points

  • Patients experienced sensory impairment and gait disorders, mainly affecting lower limbs.
  • Electrodiagnostic studies predominantly identified motor neuropathy with varying degrees of axonal and demyelinating features.
  • Magnetic resonance imaging revealed cervical cord lesions in all patients, with some presenting thoracic lesions.
  • Elevated homocysteine levels were observed in every patient evaluated for this condition.

Cite This Study

Cavalli et al. (2025) studied this question.

synapsesocial.com/papers/68c188579b7b07f3a0612529https://doi.org/10.1097/cnd.0000000000000498
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitrous oxide myelopathy: a case series2024 · 4 citations
  2. 2Understanding Neuropathy Features in the Context of Nitrous Oxide Abuse: A Combined Electrophysiological and Metabolic Approach2024 · 8 citations
  3. 3Neurological disorders induced by nitrous oxide abuse: analysis of 57 clinical cases2026
  4. 4Neurophysiological Characteristics of Nitrous Oxide‐Induced Polyneuropathy: A Case Series2026
  5. 5Nitrous Oxide as an Emerging Cause of Subacute Combined Degeneration and Polyneuropathy: A Two-Case Report2024 · 2 citations