Retrospective case series characterizes neurophysiological patterns in nitrous oxide-induced polyneuropathy, suggesting further investigation is needed.
Key Points
This case series aims to characterize the electrophysiological features of nitrous oxide-induced polyneuropathy.
Retrospective review of 12 patients with acute neurological symptoms and N2O abuse history.
All patients underwent electrophysiological testing between July 2023 and December 2024.
Data were analyzed descriptively to identify patterns and biomarkers.
PNP identified in 8 out of 12 patients, with the predominant pattern being pure motor in 5 cases.
Abnormal SSEPs observed in all assessable patients; MRI signs of SCD present in fewer cases.
Mean methylmalonic acid levels were higher in PNP patients compared to those without, with only 3 of 10 having reduced vitamin B12 levels.