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April 17, 2026Scientific ReportsOpen Access

Co-occurrence of plasmid-mediated colistin resistance gene, mcr-1 and blaCTX−M in multidrug-resistant Escherichia coli isolates from calves in Iran

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Authors

MHMehri HaeiliSBSeyyed Mohammad Reza Naghibi BijiFAFatemeh Alsahlani

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Overview

Colistin resistance co-occurs with blaCTX-M in multidrug-resistant E. coli from calves, indicating significant zoonotic risks.

Key Points

  • This study aims to characterize mcr-1-positive Escherichia coli isolates from calves in Iran, focusing on resistance mechanisms.
  • Collected rectal swab samples from diarrhetic and healthy calves.
  • Screened for colistin-resistant bacteria using PCR.
  • Conducted whole-genome sequencing on select colistin-resistant isolates.
  • All isolates carried the mcr-1.1 variant and demonstrated high resistance rates to multiple antibiotics.
  • The IncI2 plasmid type was the most prevalent among the isolates.
  • Mcr-1 elements remained stable after 10 days without colistin exposure.

Cite This Study

Haeili et al. (2026) studied this question.

synapsesocial.com/papers/69e1cfe05cdc762e9d858ea7https://doi.org/10.1038/s41598-026-48826-3
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