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April 17, 2026Obesity Science & PracticeOpen Access

Trends and Disparities in Obesity‐Related Mortality Among U.S. Adults: A CDC WONDER Analysis (1968–2025)

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Authors

FAFaizan AhmedHAHusnain AhmedAIAyesha Ishtiaq

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Overview

This analysis reports nationwide trends in obesity-related mortality in U.S. adults, highlighting significant demographic disparities.

Key Points

  • The study aims to evaluate trends in obesity-related mortality among U.S. adults and identify disparities by demographic factors.
  • Retrospective analysis using CDC WONDER mortality data from 1968 to 2025.
  • Included adults aged 25 years and older with obesity identified by ICD codes.
  • Calculated age-adjusted mortality rates (AAMRs) per 100,000 using the 2000 U.S. standard population.
  • Evaluated temporal trends using Joinpoint regression for annual percent change (APC) and average annual percent change (AAPC).
  • 211,479 obesity-related deaths recorded among U.S. adults from 1968 to 2025.
  • AAMRs increased from 1.15 to 3.32 per 100,000, peaking at 4.54 per 100,000 in 2021.
  • Mortality rates were higher among males, older adults, Black populations, and those in the Southern U.S.
  • Young adults (ages 25–44) showed the most rapid increase in mortality rates.

Cite This Study

Ahmed et al. (2026) studied this question.

synapsesocial.com/papers/69e1cffa5cdc762e9d858fbdhttps://doi.org/10.1002/osp4.70146
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Also Consider

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  1. 1Obesity mortality on the rise: A 54‐year US perspective2025
  2. 2Trends and Patterns in Obesity-Related Deaths in the US (2010–2020): A Comprehensive Analysis Using Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) Data2024 · 13 citations
  3. 3Temporal Trends and Disparities in Cardiovascular Mortality Among Adults With Obesity in the United States From 1999 to 20232026
  4. 4Concomitant mortality trends due to obesity and hypertension in the U.S.: a 20-year retrospective analysis of the CDC WONDER database2025 · 15 citations
  5. 5Rising Obesity-Related Cardiovascular Mortality in the United States, 1999–2020: Accelerating Trends and Widening Disparities2025