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January 14, 2021BMC CancerOpen Access

Development of an engineered peptide antagonist against periostin to overcome doxorubicin resistance in breast cancer

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Why the study?

Does an engineered peptide antagonist against periostin reduce doxorubicin resistance in breast cancer?

Population

Breast cancer (BCA) models

Design

Preclinical

Authors

KOKhine Kyaw OoSiriraj HospitalTKThanpawee KamolhanSiriraj HospitalASAnish SoniMahidol University

Discussion

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Implication

May support anti-PN peptide development for chemoresistant breast cancer; leaves open human translation.

Structured PICO

Does an engineered peptide antagonist against periostin reduce doxorubicin resistance in breast cancer?

P
Population
Breast cancer (BCA) models
I
Intervention
Engineered peptide antagonist against periostin (anti-PN peptide)
O
Outcome
Reduction of PN-induced chemoresistance (doxorubicin resistance)

An engineered peptide antagonist against periostin shows potential to overcome doxorubicin resistance in breast cancer.

Cite This Study

Oo et al. (2021) studied this question.

synapsesocial.com/papers/69e28cef4ffd78e822a46d79https://doi.org/10.1186/s12885-020-07761-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Editorial: Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae?2018 · 1,041 citations
  2. 2Differences in integrin expression and signaling within human breast cancer cells2011 · 205 citations
  3. 3Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker2010 · 157 citations
  4. 4Prognostic Value of Preoperative Serum Levels of Periostin (PN) in Early Breast Cancer (BCa)2015 · 39 citations
  5. 5Structural characterizations of human periostin dimerization and cysteinylation2018 · 33 citations