Evidence for a shift towards a proinflammatory/pronociceptive signature of gut dysbiosis in patients with axial chronic low back pain: a preliminary cross-sectional analysis

April 1, 2026Journal of PainOpen Access

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Key Points

This research aims to investigate the role of gut microbiome in axial chronic low back pain and its mechanisms.
Cross-sectional design with axial chronic low back pain patients and healthy controls.
Participants completed the NIH minimal dataset for chronic low back pain.
Rectal swabs collected for 16S rRNA sequencing to analyze microbiome composition.
Identified altered gut microbial colonization in axial chronic low back pain patients.
Increased abundance of formate- and succinate-producing bacteria was observed.
Reduced levels of butyrate, propionate, and acetate-producing bacteria were noted.
Results suggest a proinflammatory/pronociceptive microbial shift associated with chronic low back pain.

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Cross-sectional analysis shows gut dysbiosis in axial chronic low back pain, suggesting underlying mechanisms of pain.

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Saravanan et al. (2026) studied this question.

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