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April 16, 2026CellsOpen Access

Correction: Alobaidi et al. Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth. Cells 2025, 14, 248

Ryyan Alobaidi Nusrat Islam Toni Olkey Yogameenakshi Haribabu Mathew Shamo Peter Sykora Cynthia M. Simbulan‐Rosenthal Dean S. Rosenthal

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Key Points

To evaluate the effects of combined MEK and AKT inhibition on melanoma stem cell apoptosis and tumor growth.
Combined MEK and AKT inhibition in melanoma cell lines
Assessment of apoptosis rates in stem cells
Evaluation of tumor growth metrics in NRAS-driven models
Combined inhibition led to significant increase in apoptosis rates of melanoma stem cells
Blocked tumor growth in NRAS-positive models
Demonstrated synergistic effects when both pathways were targeted

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Implication

Correction reports combinational inhibition of MEK and AKT induces apoptosis in melanoma stem cells, implying a potential cancer treatment strategy.

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Cite This Study

Alobaidi et al. (2026) studied this question.

synapsesocial.com/papers/69e31fcb40886becb653ef86 https://doi.org/10.3390/cells15080704

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Abstract LB452: Effects of AKT1, 2, and 3 knock-out by CRISPR-Cas9 in CD133+human melanoma stem cells treated with MEK and AKT inhibitors2024
2Abstract 4819: Gene knockout or selective inhibition of AKT-3, but not AKT-1 or AKT-2 isoform, enhances apoptosis in CD133+ melanoma cancer stem cells treated with the MEK inhibitor trametinibOriginal Research · 2026
3Figure S1 from Genetic Silencing of AKT Induces Melanoma Cell Death via mTOR Suppression2024
4Abstract 1878: Cotargeting B-Raf and ACLY in Ras mutant cells leads to synergistic loss of cell viability and apoptosis.Original Research · 2026
5Data from Genetic Silencing of AKT Induces Melanoma Cell Death via mTOR Suppression2024

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