PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 18, 2026Cells0 citationsOpen Access

Correction: Alobaidi et al. Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth. Cells 2025, 14, 248

View Full Paper
RARyyan AlobaidiNINusrat IslamTOToni Olkey

Key Points

  • To evaluate the effects of combined MEK and AKT inhibition on melanoma stem cell apoptosis and tumor growth.
  • Combined MEK and AKT inhibition in melanoma cell lines
  • Assessment of apoptosis rates in stem cells
  • Evaluation of tumor growth metrics in NRAS-driven models
  • Combined inhibition led to significant increase in apoptosis rates of melanoma stem cells
  • Blocked tumor growth in NRAS-positive models
  • Demonstrated synergistic effects when both pathways were targeted

Abstract

In the original publication ...

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Alobaidi et al. (2026) studied this question.

synapsesocial.com/papers/69e31fcb40886becb653ef86https://doi.org/10.3390/cells15080704
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Capivasertib combines with docetaxel to enhance anti-tumour activity through inhibition of AKT-mediated survival mechanisms in prostate cancer2024 · 20 citations
  2. 2Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth2025 · 5 citations
  3. 3The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma2017 · 70 citations
  4. 4CRISPR-Cas9 Knockdown and Induced Expression of CD133 Reveal Essential Roles in Melanoma Invasion and Metastasis2019 · 37 citations
  5. 513. Cancers attributable to solar (ultraviolet) radiation exposure in the UK in 20102011 · 232 citations