What question did this study set out to answer?

This study aims to investigate the effects of maternal Bisphenol S exposure on testicular development and sperm function in male offspring.

April 18, 2026Small

Maternal Bisphenol S Exposure Impairs Testicular Development and Sperm Function in Male Offspring by Disrupting the Immune‐Endocrine Network

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Gestational exposure to Bisphenol S disrupts testicular health in male offspring, indicating potential reproductive toxicity.

This study aims to investigate the effects of maternal Bisphenol S exposure on testicular development and sperm function in male offspring.
Mice were exposed to bisphenol S during gestation at varying doses.
Integrated transcriptomic, physiological, and molecular analyses were performed.
Deconvolution analysis assessed immune cell infiltration and Leydig cell loss.
Quantitative real-time PCR validated dysregulation of key genes.
Western blotting analyzed protein-level changes in testicular tissues.
Maternal exposure to bisphenol S impaired testicular development and reduced sperm motility.
Aberrant activation of immune and inflammatory pathways was observed.
Significant downregulation of HLA-DPB1 was noted in testicular tissues.
Leydig cell loss and increased T-cell infiltration were identified in the testes.
Enhanced collagen deposition was found in the interstitial tissue of the testes.

Li et al. (2026) studied this question.

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