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April 18, 2026Scientific ReportsOpen Access

Characteristics and immune dynamics of peripheral blood immune cells and cytokines in individuals with chronic hepatitis B virus infection

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Authors

LXLixin XiaoZDZhuanli DongYHYao He

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Overview

Cross-sectional study analyzes immune responses and cytokine levels in chronic hepatitis B patients, suggesting potential biomarkers for disease progression.

Key Points

  • This study aims to characterize changes in peripheral blood immune cells and cytokines in chronic hepatitis B patients.
  • Cross-sectional study design involving CHB patients and healthy controls
  • Multiparametric flow cytometry used to detect immune cell subsets
  • Cytokines/chemokines measured using Luminex discovery assay
  • Data compared between groups and adjusted for age and gender using ANOVA
  • Initial CHB patients had higher total B cell frequency but lower CD4 + T cell proportion compared to healthy controls
  • CXCL10 levels were significantly elevated in CHB patients and correlated with B cell frequency
  • In late-stage infection, NK cell frequency was lower, while T cell frequency increased
  • Higher levels of key cytokines were observed in late-stage patients compared to CHB and healthy controls

Cite This Study

Xiao et al. (2026) studied this question.

synapsesocial.com/papers/69e3207940886becb653f7f6https://doi.org/10.1038/s41598-026-48947-9
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