Integrating contextual determinants and polygenic risk to examine dementia and late‐life cognition in the Multi‐Ethnic Study of Atherosclerosis

Key Points

• The aim is to understand how contextual factors and genetic risk contribute to dementia and cognitive decline in older adults.
• Analyzed data from the Multi-Ethnic Study of Atherosclerosis
• Adjusted for age, sex, education, and genetic risk
• Examined the impact of contextual determinants on dementia and cognition
• Contextual determinants show a significant association with dementia
• Late-life cognition is also influenced by these determinants after adjustments
• Polygenic risk factors contribute to understanding dementia risk.