Key result
Prediabetes linked to a modest, dose-dependent increase in AF risk.
Why the study?
Does prediabetes increase the risk of atrial fibrillation?
Meta-Analysis
Does prediabetes increase the risk of atrial fibrillation?
Prediabetes is associated with a dose-dependent increase in the risk of atrial fibrillation, suggesting dysglycemia contributes to AF pathogenesis prior to overt diabetes.
May warrant AF vigilance in prediabetes; hypothesis-generating for glycemic intervention trials to prevent AF.
Prediabetes is associated with a modest but statistically significant increase in AF risk, with evidence of a dose-dependent relationship across the glycemic spectrum. These findings suggest that dysglycemia may contribute to AF pathogenesis before the clinical threshold for diabetes is reached. Further research is needed to determine whether glycemic interventions in prediabetes can reduce AF incidence and to elucidate the mechanistic pathways linking intermediate hyperglycemia to atrial arrhythmogenesis.
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Diyab et al. (2026) conducted a meta-analysis in Prediabetes and Atrial Fibrillation. Prediabetes was evaluated on Atrial Fibrillation risk. Prediabetes is associated with a modest but statistically significant increase in atrial fibrillation risk, with evidence of a dose-dependent relationship across the glycemic spectrum.
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