Key result
Diabetes linked to increased AF risk via chronic hyperglycemia, glucose fluctuations, and dysregulated metabolism.
Why the study?
Atrial fibrillation has a complex pathogenesis that remains incompletely understood, and emerging evidence highlights an elevated risk driven by hyperglycemia, glucose fluctuations, and dysregulated glucose metabolism in diabetes.
This review summarizes the mechanisms linking diabetes-induced glucose metabolic dysregulation, including hyperglycemia and glycemic variability, to the pathogenesis of atrial fibrillation.
Supports mechanistic pathways linking diabetes to AF; leaves open whether targeting glycemic variability reduces incidence.
Atrial fibrillation (AF) is the most prevalent persistent arrhythmia in clinical practice, with a complex pathogenesis that remains incompletely understood. Emerging evidence underscores a strong association between diabetes and the occurrence of AF, highlighting a significantly elevated risk among diabetic patients. This increased susceptibility is not solely attributable to chronic hyperglycemia but is also shaped by blood glucose fluctuations and dysregulated glucose metabolism. In this review, we summarize the mechanisms by which hyperglycemia and blood glycemic variability contribute to the onset of AF, and the potential involvement of abnormal glucose metabolism pathways and metabolic disturbances induced by diabetes in the pathogenesis of AF.
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Chen et al. (2026) conducted a review in Atrial fibrillation and diabetes. Diabetes increases the risk of atrial fibrillation through mechanisms involving chronic hyperglycemia, blood glucose fluctuations, and dysregulated glucose metabolism pathways.
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