What question did this study set out to answer?

To assess humoral immunogenicity of SARS-CoV-2 mRNA vaccines in individuals with HIV, focusing on the influence of CD4 T-cell counts.

April 18, 2026MicroorganismsOpen Access

Humoral Immunogenicity of SARS-CoV-2 mRNA Primary Vaccination Among People with HIV

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Authors

DNDaniel K. NomahGeneralitat de Catalunya ARAlba G. RoblesVall d'Hebron Institut de Recerca ABAndreu BrugueraGeneralitat de Catalunya

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Implication

Evaluation of humoral responses to mRNA vaccines in HIV-positive individuals with varied CD4 counts, indicating immune status influences vaccine effectiveness.

Key Points

To assess humoral immunogenicity of SARS-CoV-2 mRNA vaccines in individuals with HIV, focusing on the influence of CD4 T-cell counts.
Studied 57 individuals with HIV categorized by CD4 count (<200 and ≥200 cells/µL) and 12 HIV-negative controls.
Measured neutralizing antibody titers against SARS-CoV-2 variants after vaccination at one month and six months.
Used a luciferase-based neutralization assay for titration of antibody responses.
Individuals with CD4 counts ≥ 200 cells/µL exhibited significantly higher neutralizing titers at both one and six months.
No overall group differences in neutralizing responses to the BA.5 variant at one month, but higher titers were observed at six months for those with CD4 ≥ 200 cells/µL.
Positive correlation between neutralizing titers and CD4 counts was identified among individuals with HIV.

Cite This Study

Nomah et al. (2026) studied this question.

synapsesocial.com/papers/69e320fd40886becb65402c0 https://doi.org/10.3390/microorganisms14040893

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Implication

Evaluation of humoral responses to mRNA vaccines in HIV-positive individuals with varied CD4 counts, indicating immune status influences vaccine effectiveness.

Humoral Immunogenicity of SARS-CoV-2 mRNA Primary Vaccination Among People with HIV

Discussion

Member takes

Implication

Key Points

Cite This Study

Humoral Immunogenicity of SARS-CoV-2 mRNA Primary Vaccination Among People with HIV

Discussion

Member takes

Implication

Key Points

Cite This Study

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