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April 18, 2026Advanced ScienceOpen Access

Glomage : A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models

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Authors

MSMaximilian SchindlerTLTim LangeSBSophia‐Marie Bach

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Overview

Multimodal platform enhances glomerular profiling in zebrafish and mice, suggesting potential in drug discovery.

Key Points

  • The research aims to develop a platform for scalable analysis of glomeruli to facilitate drug discovery for chronic kidney disease.
  • Developed a high-throughput platform called Glomage for volumetric imaging and RNA extraction.
  • Isolated and stained hundreds of glomeruli from zebrafish larvae.
  • Adapted the protocol for isolated mouse glomeruli to assess pathological features.
  • The platform enables rapid and reproducible quantification of podocyte number and structure.
  • It identifies key pathological features like age-related podocyte depletion.
  • Compatibility across species demonstrates the platform's versatility and broad applicability.

Cite This Study

Schindler et al. (2026) studied this question.

synapsesocial.com/papers/69e3211640886becb6540440https://doi.org/10.1002/advs.202523662
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