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This review aims to explore the roles of small RNAs in mediating plant defense mechanisms and cross-species interactions.

Small RNAs as systemic signals in plant defense: mechanisms, challenges, and future directions

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This review aims to explore the roles of small RNAs in mediating plant defense mechanisms and cross-species interactions.
Synthesized current evidence for mobile small RNA signaling in plants.
Examined mechanisms of RNA stabilization by RNA-binding proteins and Argonaute complexes.
Discussed challenges in RNA uptake variability and environmental stability.
Highlighted the role of small RNAs in systemic silencing across plant tissues.
Described two RNA-based strategies for crop protection: Host-Induced Gene Silencing and Spray-Induced Gene Silencing.
Identified bioinformatic and regulatory challenges in deploying mobile RNAs for sustainable agriculture.

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The review demonstrates the role of small RNAs in plant defense, suggesting pathways to enhance crop protection.

Wekesa et al. (2026) studied this question.

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