DBU-Mediated 3+2 Annulation of 3-Hydroxyisoindolinones with Vinylsulfonium Salts: An Efficient Approach to Functionalized Oxazolo2,3-aisoindolones

Key Points

• This research aims to synthesize functionalized oxazolo[2,3-a]isoindolones through a specific chemical reaction.
• Utilized DBU-mediated cascade [3+2] annulation reaction.
• Combined 3-hydroxyisoindolinones with vinylsulfonium salts.
• Synthesized a variety of 2,3-dihydrooxazolo[2,3-a]isoindol-5-one derivatives.
• Successfully prepared a broad range of tricyclic isoindolone products.
• Demonstrated the efficiency of the reaction in producing complex structures.
• Highlighted the versatility of the synthesized derivatives.