What question did this study set out to answer?

This study aims to evaluate the efficacy and safety of lipid-based amphotericin B formulations versus conventional deoxycholate in treating cryptococcal meningitis.

April 18, 2026Medical Mycology

Lipid-based amphotericin B formulations (ABCD/L-AmB) were associated with better outcomes than deoxycholate (AmB-d) in non-HIV-associated cryptococcal meningitis: A retrospective cohort study

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Authors

JLJunyu LiuSun Yat-sen University JLJia LiuSun Yat-sen University MLMin LiSun Yat-sen University

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Implication

Retrospective cohort study shows lipid-based amphotericin B improves outcomes in non-HIV CM, suggesting better safety.

Key Points

This study aims to evaluate the efficacy and safety of lipid-based amphotericin B formulations versus conventional deoxycholate in treating cryptococcal meningitis.
Retrospective cohort analysis of 199 patients divided into three treatment groups.
Compared outcomes of ABCD, L-AmB, and AmB-d over a treatment period.
Evaluated clinical improvement, renal impairment rates, and long-term survival.
Lipid-based groups (ABCD and L-AmB) showed significantly better clinical improvement at two weeks.
Lower rates of renal impairment noted in lipid-based groups compared to AmB-d.
One-year survival analysis indicated better outcomes in the lipid-based formulation groups.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69e3215140886becb6540791 https://doi.org/10.1093/mmy/myag033

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Lipid-based amphotericin B formulations (ABCD/L-AmB) were associated with better outcomes than deoxycholate (AmB-d) in non-HIV-associated cryptococcal meningitis: A retrospective cohort study

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Key Points

Cite This Study

Lipid-based amphotericin B formulations (ABCD/L-AmB) were associated with better outcomes than deoxycholate (AmB-d) in non-HIV-associated cryptococcal meningitis: A retrospective cohort study

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Cite This Study

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