Organoid Models through the Lens of Metabolomics: A Systematic Review of Experimental Applications and Analytical Approaches

Martina Lombardi; Andrea Ingenito; Antonietta Santoro; Jacopo Troisi

doi:10.1039/d6an00186f

January 1, 2026The AnalystOpen Access

Organoid Models through the Lens of Metabolomics: A Systematic Review of Experimental Applications and Analytical Approaches

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Key Points

The aim is to explore the use and analytical methods of organoid models in experimental biology with a focus on metabolomics.
Systematic review of existing literature on organoid models and metabolomics
Analysis of experimental applications in various biological contexts
Evaluation of analytical techniques utilized in metabolomics
Organoid models offer superior recapitulation of tissue structures compared to traditional cultures
Metabolomics provides insights into metabolic pathways active within organoid systems
Diverse applications in cancer research, drug development, and regenerative medicine have been identified

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Implication

This review examines the applications and analysis of organoid models in experimental biology, highlighting their importance.

Abstract

Organoid models have transformed experimental biology by enabling three-dimensional systems that recapitulate tissue architecture, cellular heterogeneity, and metabolic activity patterns more faithfully than conventional in vitro cultures. In parallel, metabolomics...

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Lombardi et al. (2026) studied this question.

synapsesocial.com/papers/69e3215140886becb654088d https://doi.org/10.1039/d6an00186f

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Organoid Models through the Lens of Metabolomics: A Systematic Review of Experimental Applications and Analytical Approaches

Key Points

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Implication

Abstract

Discussion

Cite This Study

Organoid Models through the Lens of Metabolomics: A Systematic Review of Experimental Applications and Analytical Approaches

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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