Zinc chloride-catalyzed synthesis of indole-based α-aminophosphonates with potent antimicrobial and anticancer activities: in vitro and in silico evaluation

Key Points

• The aim is to synthesize and evaluate α-aminophosphonates as potential dual-action antimicrobial and anticancer agents.
• Synthesis of α-aminophosphonates using zinc chloride as a catalyst
• Testing antimicrobial activity against various bacterial strains
• Assessing anticancer efficacy in cancer cell lines
• Using in silico methods to predict interactions and effectiveness
• Identified α-aminophosphonates showed significant antimicrobial activity
• Demonstrated potent anticancer properties against specific cancer cells
• In silico evaluations indicated promising interaction profiles with biological targets