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April 18, 2026Cancer Cell InternationalOpen Access

FcγR-driven chimeric receptor T cells in cancer therapy: a novel frontier in antibody-guided immunotherapy

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Authors

HMHany E. MareiMansoura UniversityGPGiacomo PozzoliUniversità Cattolica del Sacro CuoreSCSara CaratelliNational Academies of Sciences, Engineering, and Medicine

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Implication

This review demonstrates FcγR-driven chimeric receptor T cells improve tumor targeting in cancer, suggesting a novel therapeutic approach.

Key Points

  • The central aim is to explore the potential of FcγR-based chimeric receptor T cells in enhancing cancer therapy.
  • Review of current literature on FcγR-CR T cells
  • Analysis of preclinical developments and mechanisms of action
  • Discussion of future strategies for improving specificity and safety
  • FcγR-CR T cells can enhance targeting of solid tumors compared to traditional CAR T cells
  • Potential to overcome limitations of tumor heterogeneity and immunosuppressive environments
  • Future strategies include using engineered FcγRs and combining with immune checkpoint inhibitors

Cite This Study

Marei et al. (2026) studied this question.

synapsesocial.com/papers/69e3216540886becb6540ac1https://doi.org/10.1186/s12935-026-04258-7
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